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Carnitine plays a buffering role by absorbing excessive acetyl groups in the PDC reaction and promoting more efficient matching of carbohydrate oxidation, rather than simply enhancing exercise performance by increasing the fat oxidation rate
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Previously, a double-blind clinical trial reported that the co-ingestion of 120 mg of a Ginkgo biloba extract together with 500 mg metformin did not significantly change the metabolism of metformin in healthy individuals or in individuals with type 2 diabetes mellitus (Kudolo 2006)