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Signs to look out for to detect potential problems include: persistent tiredness, dry skin, unexplained weight gain or loss, difficulty concentrating and memory problems, irregular bowel movements, as well as irregular menstrual cycles in women and, in some cases, swelling of the neck also known as a goitre which indicates that the gland is underactive

Digital tools and AI help pick participants, but doctors and patients are essential too

Studies have shown that appropriate folate intake prevents neural tube defects (developmental issues with the brain and spinal cord), increases birth weight, and may also prevent spontaneous abortion and deformities of the mouth, face and heart

SG is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis

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Your doctor may advise a bone scan to monitor the progress of your treatment