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3 Evolution of GLP-1-based therapeutics 3.1 First-generation GLP-1RAs The development of GLP-1 receptor agonists stemmed from the significant finding that natural GLP-1 had an exceptionally short half-life of about 1.5 to 5 min, due to its rapid degradation by the enzyme DPP-4 (Campbell and Drucker 2013) (Fig
Ondansetron (commonly known as Zofran) effectively controls nausea when taken 30 minutes before meals
The 2023 JAMA meta-analysis of 118 clinical trials confirmed it as a first-line pharmacotherapy for AUD, with a number needed to treat of 11 to prevent return to heavy drinking
![Cardiovascular disease continuum-GLP-1 action. Adapted from [46]](https://www.researchgate.net/publication/357072789/figure/fig1/AS:1146405179654167@1650335702879/Cardiovascular-disease-continuum-GLP-1-action-Adapted-from-46.png)
