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Pemvidutide is an investigational peptide-based GLP-1/glucagon dual receptor agonist for the treatment of obesity and and non-alcoholic steatohepatitis (NASH) Pemvidutides unique dual activation approach is believed to mimic the complementary effects of diet (via GLP-1) and exercise (via glucagon) on weight loss Twenty four-week data from 160 patients detailed by Medscape showed that different doses of pemvidutide (1.2 mg, 1.8 mg, or 2.4 mg) led to promising weight and cardiovascular improvements

In March 2024, the FDA further approved Wegovy to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with established cardiovascular disease and either obesity or overweight