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Tirzepatide was never on the 503B Bulks List, and the April 30 proposed rule would formalize permanent exclusion
For context, semaglutide alone achieved 14.9% weight loss in the same trial
All three medications have been extensively studied in large-scale clinical trials and are generally well tolerated
Understanding how these medications work throughout the body is important when considering potential side effects, as GLP-1 receptors are present in multiple organ systems beyond the pancreas, including the gastrointestinal tract, cardiovascular system, and central nervous system
A: If side effects are severe, persistent, or unusual, or if you experience symptoms like pancreatitis or severe allergic reactions, contact your provider immediately
These effects together can help lead to weight loss and better control of blood sugar
