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Simultaneously, catalytically produced hydrogen peroxide (H 2 O 2 ) activates the protein transient receptor potential melastatin 2 (TRPM2) ion channel, promotes calcium influx, activates macrophages, and induces systemic immune response (Fig
Lata PF, Pigarelli DL
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6 Emerging clinical applications 6.1 Non-alcoholic steatohepatitis (NASH)/non-alcoholic fatty liver disease (NAFLD) Studies investigating GLP-1 receptor agonists for the prevention of NAFLD/NASH indicate potential effectiveness via several molecular mechanisms
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