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These inadequacies emphasize the need for a more comprehensive, unifying mechanism to elucidate the complex relationship between CVDs and cognitive impairment at cellular and molecular levels, and underscore the urgency of further research into mitochondrias role in this comorbidity

307 Renal metabolic mechanisms and diseases Emerging evidence increasingly supports the pathogenic role of hyperuricemia in both the onset and progression of chronic kidney disease (CKD)

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19), indicating potential toxicity beyond the 2.5 M dosage and poor target specificity

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In addition to experimental methods, theoretical methods [49,50,51,52,53] have been used to elucidate the properties and mechanisms of vitamin B12 cofactor catalysis in enzymatic processes [54,55,56,57,58,59]