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NAD+ plays a crucial role in various cellular processes, such as energy production, DNA repair, and the regulation of gene expression
Our choice of metformin as a proof-of-concept test as a CI inhibitor 79 in these orthotopic models was based on several factors: (1) it could easily be taken forward safely into in vivo studies with known target concentrations
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Multi-omics integration is reshaping our understanding of these processes
Furthermore, it enriched beneficial gut microbes and increased SCFA production
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