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[2] Phenobarbital is metabolized by CYP2C9 and 2C19, which may lead to drug-drug interactions

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Total weight loss at 48-68 weeks on the combination is difficult to predict without clinical trial data, but based on individual compound data (retatrutide at 24-28.7% and the additive benefit seen with CagriSema), a reasonable estimate for the combination is 25-35% total body weight reduction in high responders

Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion by continuous somatostatin infusion