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The core mechanisms underlying these protective effects involve inhibition of oxidative stress and inflammatory pathways (e.g., regulation of NF-B, Nrf2, AGEs/RAGE/Nox4), reduction of apoptosis and necrosis, enhancement of endogenous antioxidant defenses (e.g., increased antioxidant enzyme activity and Hsp70/90 expression), and improvement of BTB integrity (61, 88)

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