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28 days) hydrochloride improves cognitive function in the cognitive impairment model of aged rats, enhances synaptic plasticity in the hippocampus, and increases the expression of brain-derived neurotrophic factor (BDNF) [3]
These therapies differ by active ingredient, delivery method, dosing frequency, and FDA-approved indication
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Recently completed CARMELINA and CAROLINA trials also suggested that linagliptin did not increase HF hospitalization compared to placebo or glimepiride [57, 58]
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