The SURMOUNT-1 trial published in the New England Journal of Medicine demonstrated remarkable results: participants achieved an average weight loss of 15% to 20.9% of their total body weight over 72 weeks, compared to just 3.1% in the placebo group
fermentum (obtained from a commercial product) as controls for our in vitro studies
Pharmacoepidemiol Drug Saf 2024;33(1):e5673
Cell viability and ROS and glutathione intracellular content of cells cultured in liquid medium were assessed by flow cytometry analysis of cells stained for 30 min in the dark with 0.025 M calcein-AM (ThermoFisher Scientific, C3099) at room temperature, 50 M Dichlorodihydrofluorescein-diacetate (DCFDA, ThermoFisher Scientific, D399) at 37 C, and 10 M monochlorobimane (ThermoFisher Scientific, M1381MP) at 37 C, respectively
For details on insurance coverage criteria and challenges with compounded GLP-1s, see this Harvard Medical School perspective
These include: Nausea and vomiting (very common, affecting more than 1 in 10 patients) Diarrhoea or constipation Abdominal discomfort or bloating Reduced appetite These symptoms often diminish over several weeks as the body adjusts to the medication