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By promoting immune cell migration to sites of genuine infection, it redirects immune activity away from self-tissue and toward actual threats
More serious B12 deficiencies have the potential to impair heart and neurological function, leading to a wide range of serious symptoms, including but not limited to: tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia and changes in reflexes
doi:10.1056/NEJMoa2107519
Quick Takeaways Human sleep trials used 25 nmol/kg IV for 7 consecutive nights The commonly used 100250 mcg subcutaneous protocol lacks direct clinical validation DSIP demonstrates an unusually wide safety margin in animal and human research Most evidence comes from small 1980s pilot studies, not modern RCTs What DSIP Actually Is (And Why Its Misunderstood) DSIP is a nine-amino-acid neuropeptide first isolated in 1977 from the cerebral venous blood of sleeping rabbits
A randomised controlled trial is considered the gold standard of clinical evidence
