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The effect size interpretation followed the common criteria for both Hedges g (Hedges and Olkin, 2014) and Cohens d (Cohen, 2013): small (0.2), medium (0.5), or large (0.8) (Brydges, 2019)
Peptides are not thyroid medications, but metabolic shifts may alter symptoms or lab values
As a class effect shared with GLP-1 receptor agonists, there is a precautionary concern regarding thyroid C-cell tumours, based on animal studies
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