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At our clinic, MOTS-c is prescribed for patients whose goals include improved body composition, better metabolic function, and increased physical endurance
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However, further research is needed to confirm that the improvements in systemic inflammation and joint symptoms observed with these therapies are also tied to improvements in joint inflammation.
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In a 2-year caloric restriction clinical trial there was a modest slowing of the pace of aging by DunedinPACE, with minimal change in other clocks 24
However, these analyses often included smaller trials with shorter follow-up, which may increase heterogeneity and reduce reliability regarding long-term cardiovascular and safety outcomes
