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Sleep Deprivation Selectively Upregulates an Amygdala-Hypothalamic Circuit Involved in Food Reward

That sentence deserves emphasis because it directly contradicts the fear that the boxed warning creates

These personalized interventions hold the potential to mitigate T21-related comorbidities and enhance the effectiveness of behavioral therapies

Patients should be alert to warning signs requiring urgent medical attention, including severe abdominal pain (especially if radiating to the back), persistent vomiting, or signs of gallbladder disease or pancreatitis

Starting at a low dose and titrating up slowly is a key strategy used to improve tolerability