This is a type of anemia that is known to cause weight gain
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Raises NAD+ and SAM The same study showed that NAD+ and S-adenosyl-methionine (SAM) both went up after NNMT inhibition
As of June 2026, AOD-9604 is listed as Nominated but Withdrawn , meaning it is no longer actively under Category 2 nomination
Importantly, persistently high serum B12 in the absence of supplementation should prompt GP assessment, as it may indicate underlying disease processes
In proof-of-concept studies, NNMT inhibitors (NNMTis) have demonstrated promise as potential treatments for obesity and obesity-related metabolic comorbidities (e.g., T2D, fatty liver) 8,9,13