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While recent incretin-based therapies have provided pharmaceutical inroads into treatment of obesity, there remains an ongoing need for additional medicines with distinct modes of action as independent or complementary therapeutics

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When converted to folate, it acts as a cofactor in many important biological reactions

Nevertheless, personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN 2) represents an absolute contraindication to tirzepatide use

Below is an overview of the principal research areas documented in preclinical studies