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Published preclinical work has used diet-induced-obese and GLP-1R knockout rodent models alongside indirect calorimetry and pair-feeding designs as experimental tools to study how the three receptor pathways relate to measured signaling readouts, plus cell and tissue systems probing hepatic lipid handling

Phase 2 trial data published in the New England Journal of Medicine in 2023 demonstrated substantial weight loss and metabolic benefits across both obese and type 2 diabetes populations

Assembly of transgenic human P301S Tau is necessary for neurodegeneration in murine spinal cord

95% CI, 0.72-0.98) and rectal cancer (HR = 0.72

This cycle was repeated four times, ensuring that each rat was exposed to every dose, which allowed for within-subject comparisons

doi: 10.1159/000442721 13 TakYJLeeSY