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A systematic review of the effect of hydration on hunger suggests that drinking liquids 30 to 120 minutes before meals results in less food intake during the meal

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In an embryofetal development study in pregnant cynomolgus monkeys, subcutaneous doses of 0.015, 0.075, and 0.15 mg/kg twice weekly (1.0-, 5.2-, and 14.9-fold the MRHD) were administered throughout organogenesis, from Gestation Day 16 to 50