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If you notice any adverse effects after you start taking vitamin B12 supplements, you should discontinue use immediately

Most patients notice appetite changes within days and visible weight loss within 2-4 weeks, with continued progress over several months of treatment

Nutr Rep Internat 1984;29:1071-1079

75 (2 Suppl): 637644

Reported VAS ratings were similar for traders versus nontraders for untreated PWS (38.64 vs 38.95, P = 0.89) and PWS with controlled obesity (57.36 vs 55.14, P = 0.35) but varied for PWS with controlled obesity and hyperphagia (70.70 vs 64.46, P = 0.02)

However, this practice is not widespread and is still considered an off-label use of the drug