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How much less effective are oral GLP-1 medications compared to injections

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If a target dose is 250 micrograms, draw 0.1 mL (10 units on a U-100 insulin syringe)

Care 32 , 10231025 (2009)

But because it must be taken daily on an empty stomach with minimal water, and because absorption varies significantly day to day, achieving consistent steady-state levels takes longer and is less predictable