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Mutair AA, Alhumaid S, Shamsan A, et al
The anatomical distribution of GLP-1R throughout the reproductive system and several preclinical evidence support that GLP-1 can modulate the HPG axis activity at different levels, thus connecting reproductive functions, metabolic system, nutrition, and energy homeostasis mechanisms
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They were all large-scale trials involving 3,000 to 18,000 patients who were either at high risk of or having established ASCVD, with trial durations ranging from 15 to 60 months
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