It was first isolated, as an inhibitor of gastric acid secretion, from porcine small intestine crude extracts
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Its tri-agonist receptor activity supports research into receptor pharmacology, endocrine pathway regulation, lipid metabolism, hepatic signaling, and cross-tissue metabolic communication in controlled laboratory and translational research environments [1][5]
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One possible mechanism might be that the modifications of gut microbiota might influence the expression of gut G-protein coupled receptors (Rousseaux et al., 2007), beside manipulating host feeding behavior through hormonal and neural mechanisms (Alcock et al., 2000)