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Recent advances in understanding multiple sclerosis

Neurochem Res 2003

The report was uncontrolled, unblinded, not randomized, had no comparator arm, used patient-reported outcomes rather than validated pain instruments, and did not publish dose, effect size, confidence intervals, p-values, or systematically collected adverse events limitations that severely constrain any clinical inference

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In MM medium, only the gdh3 / gdh3 mutant showed a significantly lower concentration of NADH, NADP + , and NADPH than the wild-type strain

Study Design Considerations Research protocols must specify exact dosing schedules and concentrations