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The Future of MOTS-C Research: What Is Coming The MOTS-c field is advancing rapidly, with several threads of research likely to reshape clinical dosing recommendations within the next five years
While the experimental autoimmune encephalomyelitis (EAE) model is closer to anti-MOG disease in etiology, cuprizone-induced demyelination relies directly on oligodendrocyte death to induce the disruption
The 2mg dose is a receptor adaptation phase, not a results phase
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In ESSENCE, the mean (SD) ELF score was 9.95 (0.98), ranging from 7.4 to 13.2, similar to results from the MAESTRO-NASH trial of resmetirom
The data were analyzed in GraphPad Prism 8 using the one site dose-response stimulation method
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