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No serious liver-related safety issues were seen, but people with advanced liver disease were not included

Weight loss typically occurs in phases: rapid initial loss during the first 36 months, continued gradual loss through month 12, and then maintenance or plateau depending on individual metabolism and lifestyle adherence

Some side effects may be easy to manage

During the first month of semaglutide therapy, most patients experience modest weight losstypically 1-2% of baseline body weight, or approximately 2 to 5 poundsas the medication is initiated at lower doses

The body has had months to adapt to GLP-1 and GIP receptor activation by this point

On keto, where meal timing is often consolidated into one or two eating windows, this fasting requirement is usually easy to accommodate