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DNA damage in leukocytes and serum nitrite concentration are negatively associated in type 1 diabetes
Exceptional safety margin No dependence or tolerance naturally occurring endogenous peptide Tolerability in clinical trials No tolerance develops with repeated doses No withdrawal symptoms upon stopping Peptide naturally present in the human body Research considerations Researcher's notes Outstanding safety profile for a bioactive peptide No serious adverse events were reported in the published studies
The Clinical Evidence STEP 1 [1] (N=1,961, NEJM 2021, DOI: 10.1056/NEJMoa2032183): 14.9% mean weight loss over 68 weeks
Combes B, Stakelum GS (1961) A liver enzyme that conjugates sulfobromophthalein sodium with glutathione
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4 Gutimmunebrain crosstalk mechanisms In PD the gut-immune-brain crosstalk acts as an integrated signaling network, with peripheral immune shifts influencing essential neuronal integrity [99]
