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Success Rate 85-90% maintain weight loss as long as medication continues and is well-tolerated

Regulators based approval on studies showing effectiveness alongside healthy lifestyle changes, supporting early obesity management and reducing related health complications

Certain nerve damage may never be fully repaired, especially if youve gone more than six months without treatment

In clinical trials, DSIP has been shown to normalize disturbed sleep and improve alertness and performance during wakefulness 4

Common Side Effects Nausea (typically improves after 2-4 weeks) Diarrhea or constipation Decreased appetite (this is the goal) Mild stomach discomfort Fatigue during dose increases When to Call Your Doctor Severe or persistent nausea/vomiting Signs of pancreatitis (severe abdominal pain) Vision changes Rapid heartbeat Signs of allergic reaction Is Semaglutide Right for You

A relevant issue that remains controversial is whether the positive impact of GLP-1RAs on hepatic histology is indirect, i.e., through their action on the pancreas or other extrahepatic tissues, or direct, i.e., through activating GLP-1R on hepatocytes