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Acknowledgements This work was supported by the National Natural Science Foundation of China (grant No

[20] [33] Oral hygiene practices can address metallic taste or altered oral sensations: Brush teeth and tongue regularly Use alcohol-free mouthwash Chew sugar-free gum or mints Rinse mouth with baking soda solution (1/4 teaspoon in 1 cup water) Taste changes often improve over weeks to months as the body adjusts to therapy, though individual experiences vary

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Take the medicine regularly at the same time each day for better treatment consistency

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