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We show (i) that PfGrx-catalyzed redox reactions outcompete uncatalyzed reactions between roGFP2 and GSH or GSSG by several orders of magnitude, (ii) that the PfGrx-catalyzed reduction and oxidation of roGFP2 occur via a mono- and not a dithiol mechanism, and (iii) that the reduction of roGFP2(S 2 ) as a model non-glutathione disulfide substrate most likely involves a rate-limiting glutathionylation in a ternary complex with a GSH molecule that is activated at the 1st glutathione-interaction site of PfGrx
Bansal, V
Antibiotic use and risk of incident kidney stones in female nurses
These require immediate medical attention
to prevent migraine headaches in adults and adolescents 12 years and older
All these observations were confirmed and supported by in vitro experimental data, including evaluation of cytotoxic effects on healthy RBCs [269,270,271]
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