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The key strategies for minimizing regain during a short break include maintaining a high protein intake of 1.6-2.2 grams per kilogram of body weight daily, continuing or increasing resistance training to preserve muscle mass, planning meals in advance so hunger does not drive impulsive food choices, monitoring weight weekly but not daily to avoid overreacting to normal fluctuations, and staying hydrated since the body may retain more water without GLP-1 mediated effects on fluid balance

Moreover, anti-inflammatory macrophages release pro-inflammatory cytokines such as IL-6 and TNF-, which stimulate myoblast proliferation and satellite cell recruitment

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Tirzepatide (Zepbound), a dual GLP-1/GIP agonist, further raised the bar, with mean weight loss exceeding 20% in the SURMOUNT-1 trial

The Benefits: Whats In a Dose

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