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Nanotechnology and smart drug delivery Nanoparticle-based drug delivery systems have emerged as promising tools in cancer therapy due to their capacity to improve pharmacokinetic profiles, enable tumor-targeted delivery, and facilitate site-specific drug release in response to the TME

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Limited clinical evidence supports simultaneous use, and the combination carries risks including elevated blood pressure, heart rate changes, and compounded gastrointestinal side effects

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Unlike traditional peptides, Dihexa is a peptidomimetic, meaning it was designed with non-natural structural elements (hexanoic acid caps on both termini) that confer resistance to enzymatic degradation and enable oral bioavailability