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examined the impact of ALC (50 mg/kg/day for a month) on the HPG axis in female rats and found that serum LH and prolactin levels were increased during the proestrous and estrous phases, while serum E 2 levels were increased during the estrous phase of the cycle

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The study had two primary endpoints, the percentage change in body weight from baseline to week 68 and attainment of at least 5% bodyweight reduction for oral semaglutide 50 mg vs