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29 cohorts, 2,358 participants) - a primary marker of autoimmune activity in Hashimoto's *Significant reduction in TSH levels in patients not on thyroid hormone replacement (SMD 0.21
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5.6 Protein aggregation -Synuclein aggregation is a hallmark of PD, forming Lewy bodies that contribute to neuronal death, particularly in dopaminergic neurons in the substantia nigra
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