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In the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial, comparing tamoxifen or anastrozole to the combination of anastrozole and tamoxifen in postmenopausal women with early breast cancer, the combination therapy arm was discontinued early as an efficacy benefit over tamoxifen therapy alone was not demonstrated

for instance, lighter skin became apparent after administering high doses for treating other diseases

Tirzepatide and semaglutide are generally safe for most people, but like any medication, they can cause side effects

If you have hyperthyroidism (overactive thyroid) or thyrotoxicosis, this should be stabilised before considering Wegovy, as uncontrolled thyroid disease can complicate weight management and increase cardiovascular risk

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It is also not meant for use in people with Type 1 diabetes