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In terms of vaccine design, maintaining the pre-fusion conformation of Env is an oft-encountered problem in the design of recombinant Env proteins as potential immunogens 27,28,29
Finley, S.C
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Ligand-induced phosphorylation of the RTKs induces recruitment of the regulatory subunit of PI3K (p85) to the RTKs, relieving the inhibitory interaction with the catalytic subunit (p110) and resulting in activation
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