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In terms of sensitivity, excluding published before 2002 and smaller studies also showed no obvious change in the primary outcomes

Pharmacol Rep 76(4):644664 Josiah SS, Famusiwa CD, Crown OO, Lawal AO, Olaleye MT, Akindahunsi AA, Akinmoladun AC (2022) Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1, TNF-, NF-B, IKB, and p53 genes in male Wistar rats

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Neuroprotective properties add another dimension to the antidepressant profile

There is no single best route, only the one that fits your goals, your schedule, and how your body responds, which is a conversation to have with your provider rather than a decision to make from a webpage