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Antioxidant system The transcription factor NRF2 modulates detoxification, antioxidant defense, and drug metabolism by upregulating genes with antioxidant response elements
Margari et al., 2018)
This may be at room temperature [20-25C (68-77F)], refrigerated [2-8 C (36 -46 F)], or frozen [-15 to -25C (5 to -13F)]
This allows assessment of tolerance before increasing to standard therapeutic doses of 1-2mg daily
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A nasal spray was tried
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![Classification of GLP-1 RAs based on different parameters [13]](https://www.researchgate.net/publication/343265981/figure/tbl1/AS:923164464906240@1597110968484/Classification-of-GLP-1-RAs-based-on-different-parameters-13.png)
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