Week 3 and week 4: building momentum Weeks three and four represent the transition from novelty to routine
In elderly individuals, chronically ill patients, or those with mitochondrial dysfunction, this conversion may be inefficient
These findings support the real-world therapeutic effectiveness of oral semaglutide outside highly controlled clinical trials
Table 1 PICOS criteria of the included studies
Glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide, achieve significant weight loss primarily through central appetite suppression [9, 10]
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