Participants reaching a weight reduction of 25% or more were 34.7% on CagriSema, 14.8% on semaglutide, and 6.5% on cagrilintide
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Morroniside activated the Wnt/-catenin signaling pathway To confirm the above results suggesting a role for Wnt/-catenin signaling, we measured the expression levels of Wnt10b, -catenin and lef1 by reverse transcription (RT)-PCR, western blotting analysis and immunofluorescence analysis after morroniside treatment for 24 h