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doi: 10.1016/j.tips.2019.04.006 167 FilosaSDi MeoFCrispiS

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Mitochondrial dysfunction in bipolar depression There has been a recent conceptualization of BD as a mitochondrial disorder, with the suggestion that energy production is increased in mania and decreased in the depressive phase [30, 31]

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Second, it enables researchers and practitioners to identify individual tolerance thresholds before reaching maximum doses