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Participants on a 12 mg Retatrutide dose lost an average of 28.3% of their body weight over 80 weeks, with up to 45.3% achieving weight losses similar to bariatric surgery outcomes

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Thus, any experiment with gene knockout mice needs to consider adaptive mechanisms that can affect signaling mechanisms and the mode of cell death

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Nature Reviews Gastroenterology and Hepatology 2022;19:753767

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