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While no significant effects were observed on movement or number of egg clusters, there was a significant decrease in growth when snails were exposed to microplastics or the combination of microplastics and ibuprofen (p = 0.021)

Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in research [PMID: 26469138] Laboratory literature summary: Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in research models Mice

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For more information, read this article which looks at the connection between thiamine deficiency and small intestinal bacterial overgrowth: When Sibo & Ibs-Constipation Are Just Unrecognized Thiamine Deficiency Thiamine also exerts direct effects on the intestinal barrier

The angiogenic action appears tied to T4s actin-binding motif: Philp et al., FASEB J 2003 demonstrated that this seven-residue site is essential for promoting endothelial migration and vessel formation

Targeted protein degradation: advances in drug discovery and clinical practice