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Curr Biol 18(14):10171024 Nobile CJ, Fox EP, Nett JE, Sorrells TR, Mitrovich QM, Hernday AD, Johnson AD (2012) A recently evolved transcriptional network controls biofilm development in Candida albicans
High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation
One difference between their model and the one reported here is that deletion of Gclc is induced in hepatocytes of adult mice (which are slowly proliferating), compared to theirs, where deletion of Gclc occurred in hepatocytes of growing animals (which are rapidly proliferating)
These mechanistic insights, primarily derived from robust preclinical models, offer a convincing theoretical basis for future translational studies aimed at validating EA as a non-pharmacologic intervention for MASLD, obesity-related liver dysfunction, and metabolic syndrome
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Vitamin C regenerates oxidized glutathione back into its active form, creating a self-reinforcing brightening cycle
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