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In this study, with a median follow-up of 25 months, the primary composite end point including cardiovascular death, MI, stroke, and hospitalization for unstable angina occurred in 406 patients (13.4%) in the lixisenatide group and in 399 (13.2%) in the placebo group (HR, 1.02

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Ding W, Chang WG, Guo XC, Liu Y, Xiao DD, Ding D, Wang JX, Zhang XJ

In a similar vein, co-incubation with L-carnitine, a quaternary amine that desensitizes the mPTP by reducing the transmembrane electrical potential, prevents the permeability transition of mitochondria exposed to colistin 48

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