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Participants were followed for up to five years after treatment initiation, with follow-up ending at drug discontinuation, switching, death, or loss to follow-up

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Studies show that lactate increases ubiquitin-specific peptidase 39 (USP39) expression in Treg cells, a crucial part of the RNA splicing complex, leading to USP39-dependent RNA-splicing mediated cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) expression in a forkhead box P3 (foxp3)-dependent manner (63)

Eating nutrient-dense foods and having smaller, more frequent meals can help

Many patients find their appetite suppression increases with each dose escalation, meaning they may need to actively eat to hit adequate nutrition targets at higher doses