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The systemic copper load from topical application is minimal, so there's generally no concern about combining routes

[5, 6] It is considered the main redox buffer in human cells owing to its large amount of reducing equivalents, [7] and is an important enzyme cofactor that serves as a neuromodulator in the central nervous system

Because mesenchymal stem cells (MSCs) have been shown to produce many specific anti-inflammatory effects in neural tissue, "these findings have led to increased interest in MSCs as a potential cell source candidate owing to their immunomodulatory effect [and] MSCs have demonstrated the capability to differentiate into astrocyte-like cells that secrete neurotrophic factors and ameliorate the motor deficits in a rodent model of PD." (4a) (4b)

[52] Diagnosis [edit] The clinical diagnosis of BPH is based on a history of LUTS (lower urinary tract symptoms), a digital rectal exam, and the exclusion of other causes of similar signs and symptoms

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