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After administration of Exendin-4, A oligomers-induced impaired axonal transport was prevented, and levels of soluble A and amyloid plaque load were decreased in APP/PS1 mice (224, 227)
Trachtman H, Nelson P, Adler S, Campbell KN, Chaudhuri A, Derebail VK, Gambaro G, Gesualdo L, Gipson DS, Hogan J, Lieberman K, Marder B, Meyers KE, Mustafa E, Radhakrishnan J, Srivastava T, Stepanians M, Tesar V, Zhdanova O, Komers R
Presented for research literature review only Gaudncio FN et al
The 2025 meta-analysis by Alfalasi and colleagues, published via PMC, synthesized data from 16 studies and 6,098 total participants
However, we must acknowledge the limitations due to the relatively short follow-up period and the small size of the study populations, especially given the lifelong nature and high prevalence of the conditions treated by the drug (obesity and T2D) worldwide
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