The direct relationship between tryptophan levels and depressive symptoms and fatigue has been demonstrated by Trp depletion experiments, as reviewed elsewhere [76], and is also of interest in the context of long-term COVID, as recent studies have shown a significant decrease in plasma Trp levels in PASC patients [48], and alterations in kynurenine pathway metabolites have been associated with cognitive impairment in long COVID patients [27], as well as with anxiety and depressive symptoms in COVID-19 survivors 6 months post-infection [66]
Elbaset MA, Mohamed B, Moustafa PE, Mansour DF, Afifi SM, Esatbeyoglu T, Abdelrahman SSM, Fayed HM (2023) Erythropoietin suppresses the hepatic fibrosis caused by thioacetamide: role of the PI3K/Akt and TLR4 signaling pathways
Its also been shown to reduce the size of carotid-intima media size (cIMT) and thus reduce the progression of carotid atherosclerotic vascular disease (2)
The question is, could other pharmacies make an absorption enhancer, coformulate it with semaglutide or tirzepatide, and have meaningful levels of drug absorbed to be able to deliver a useful pharmacological effect? Drucker says
Dual agonism with GLP-1 and amylin As WL with GLP-1 RA and amylin analogues results both from distinct and overlapping pathways, a combination of these entero-pancreatic hormones may induce a synergistic WL effect [84]
Mounjaro is FDA-approved for controlling blood sugar in adults with type 2 diabetes, similar to Ozempic and Rybelsus